Category Archives: Research

Sirukumab Set to Establish New Field

The success of protein-based drugs has seen them impact on almost every branch of modern medicine. They are useful modulators of the immune system and this power has been applied in the clinic to devise new cancer therapies with stellar success. Sirukumab is an immune modulator that dampens inflammatory responses by binding the protein interleukin-6. This has already proved effective in treating rheumatoid arthritis, however, a more radical study is examining the usefulness of sirukumab in treating depression.

ADCs: Origins and Obstacles

This is the fourth article in a series of five blog posts that are putting ADCs in the spotlight. This article will describe the origins of and obstacles faced during ADCs development from the beginning of the 20th century to today. Please read the introductory post ‘ADCs: What are they and why do they matter?’ before this post, if you are unfamiliar with ADCs. Look out for ‘ADCs: Pipeline & Progress’.

ADCs: Function & Pharmacology

This is the second article in a series of five blog posts that are putting ADCs in the spotlight. This article will describe in detail how an ADCs design can control its function and pharmacology. Please read the introductory post Antibody Drug Conjugates: What are they and why do they matter before this post, if you are unfamiliar with ADCs.